We found that single administration of recombinant IL10, CXCL1 or CCL4 attenuates the proliferation of PC cells, and simultaneously induces pro-apoptotic effects, while the stimulation of these cells with a combination of CXCL1/IL10/CCL4 synergistically increased the observed anti-tumour effects. Here, IL10 is linked to pachyonychia congenita.