Furthermore, including the R2 predictive index instead of tumor size and CEA, a multivariate analysis showed that age, CRP, and the R2 predictive index were the independent factors (HR: 17.20, 95% CI: 3.84–77.16, p < 0.001; HR: 6.76, 95% CI: 1.58–28.89, p = 0.010; HR: 8.25, 95% CI: 2.13–32.02, p = 0.002, respectively) (Table 4). This evidence concerns the gene CEACAM5 and neoplasm.