In addition, using an mRNA expression dataset containing chondrosarcoma tissue samples and the TCGA mRNA expression data set containing a heterogeneous set of soft tissue sarcomas, focusing on SUMOylation cascade components, showed comparable results, correlating high SUMO2/3 protein and high SUMO E1 and high E2 enzyme expression to poorer disease outcome. The gene discussed is SUMO2; the disease is chondrosarcoma.