The NDCS1 cell line (derived from a dedifferentiated chondrosarcoma, IDH wild type) was most sensitive to SUMO inhibition with an IC50 of 9.4 nM ML792 and the CH2879 cell line (grade 3 chondrosarcoma, IDH wild type) was the least sensitive, IC50 283 nM ML792 (Figure 3B,D). Here, IDH1 is linked to chondrosarcoma.