YAP is a co-transcription factor that induces transcription of a variety of genes related to cell proliferation (E2F and Cyr61), cell survival (survivin and Bcl2), cancer stemness markers (Oct4, Nanog, and IGF-1R), and EMT markers [11,17,18,27,30,36,57,58,78,79,80,81,82,83,84]. This evidence concerns the gene POU5F1 and cancer.