As shown in Figure 2, compared with naïve cells, sorafenib-resistant HCC cells had significantly higher expression levels of YAP, as well as of IGF-1R; IGF-1; and the mesenchymal-related proteins VIMENTIN, SNAIL1, and N-CAD, both at the transcriptional level, as shown by mRNA analysis (Figure 2A and Figure S1), and at the protein level, as shown by Western blotting analysis (Figure 2B). The gene discussed is CDH2; the disease is hepatocellular carcinoma.