PTEN and endometrium adenocarcinoma: We had previously developed a mouse model (CAG-Cre-ERT+/−Ptenfl/fl)—in which tamoxifen (TAM) injection triggers Pten deletion mostly in epithelial cells, consistently inducing endometrial adenocarcinoma [31]—and a three-dimensional (3D) polarized endometrial epithelial cell culture model [26].