First, we measured expressions of ENDOG, p-AKT, AKT and PTEN in FTC-133 follicular thyroid carcinoma cells, CAL-62 thyroid anaplastic carcinoma, HT-29 colorectal adenocarcinoma cells and U87 and U251 glioblastoma multiforme (GBM)-derived cancer cell lines. This evidence concerns the gene PTEN and cancer.