PTEN and endometrial cancer: To further understand the relationship between ENDOG and PTEN alterations we performed an in silico search showing that ENDOG expression was lower in more aggressive uterine malignancies (Figure 2b; https://www.cbioportal.org/, accessed on 1 June 2021), and that ENDOG expression correlated exclusively with PTEN gene somatic mutations in endometrial cancer (TCGA Dataset: UCEC 28 June 2013 http://explorer.cancerregulome.org/, accessed on 1 June 2021) [27] (Figure 2c,d).