Indeed, independently of the CRC model used, pevonedistat invariantly promoted upregulation of p21 and γH2Ax protein levels, thus inducing DNA damage and cell cycle arrest [14] and confirming the general mechanism of action impinging on re-replication and the CRL4–CDT2–SET8/p21 axis [27,28]. This evidence concerns the gene IL17RB and colorectal carcinoma.