Unbiased analysis of gene expression using RNA sequencing showed that transgenic expression of β-catenin affects pathways like regulation of metabolism, lymphocyte activation, adaptive immune response, MHC complex, cytokine production, antigen processing and presentation, Th1/Th2 cell differentiation, Th17 cell differentiation, cell adhesion molecules, chemokine signaling, signaling (NF-κβ, TNF and others), GVHD, allograft rejection, and autoimmunity in CD8+ and CD4+ T cells. Here, CD8A is linked to graft versus host disease.