However, published data have indicated that the IMP phenotype is not dependent on IL-4 expression specifically in Cat-Tg mice [8,31] These findings would indicate that higher Eomes expression and the IMP phenotype in Cat-Tg mice due to β-catenin overexpression allows these cells to have anti-tumor activity in a T cell-intrinsic manner [15,17]. This evidence concerns the gene CAT and neoplasm.