It was reported that the restoration of oxygen in metastatic colon cancer through Myo-Inositoltrispyrophosphate (ITPP), a nontoxic, anti-hypoxic molecule that recently has shown significant benefits in experimental cancer models, particularly when combined with standard chemotherapy, inhibits tumor spread and is accompanied by a reduction in malignant serum markers including osteopontin, leading to markedly improved animal survival. Here, SPP1 is linked to cancer.