AKT1 and colorectal carcinoma: Other signaling pathways may also regulate RUNX2 expression, as suggested by a recently published study showing that liquiritigenin, a flavonoid extracted from the roots of Glycyrrhiza uralensis, remarkably reduced the expression of RUNX2 through inactivation of the phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) pathway in HCT-116 CRC cells, and reduced both proliferation and invasion [57].