The pooled data showed that a high OPN expression was significantly associated with high tumor grades (OR = 2.24, 95% CI 1.55–3.23), lymph node metastasis (OR = 2.36, 95% CI 1.71–3.26), and distant metastasis (OR = 2.38, 95% CI 1.01–5.60). Here, SPP1 is linked to neoplasm.