Furthermore, even though p53 mutation status correlated with WEE1 inhibitor sensitivity in our panel of lung cancer cells (the two most resistant cell lines, H460 and A549, have wt-p53 and the two most sensitive cell lines, H1975 and SW900, have mut-p53), it did not correlate with sensitivity to ATR inhibition (H460 is most sensitive). This evidence concerns the gene TP53 and lung cancer.