Although no drug discovery campaigns have been reported for LIPR3, the pancreatic lipase gene family of which LIPR3 is a member has been the subject of considerable medicinal chemistry attention due to the role of the closely related LIPP protein in obesity, for which there is an FDA-approved drug (Orlistat) with an associated X-ray co-crystal structure [37]. This evidence concerns the gene PNLIP and obesity due to melanocortin 4 receptor deficiency.