Comparison of the Mardepodect-upregulated genes shared in U87MG and A172 reveals further new signatures, with genes encoding the key glioma-associated cell surface proteins GPNMB and T4S19 (TM4SF19) being upregulated in concert with the anti-apoptotic heme-degrading enzyme HMOX1, reported to facilitate glioma survival and progression [79]. The gene discussed is HMOX1; the disease is central nervous system cancer.