Several distinctive genes characterized the Mardepodect-upregulated pathway signature “PIP3 activates AKT signaling” in U87MG cells, including those encoding the EMT-promoting transcription factors SNAI1 (Snail) and SNAI2 (Slug), which have key roles in tumor growth, invasion, and metastasis in GBM [49,50]. The gene discussed is AKT1; the disease is neoplasm.