Moreover, a drug screening analysis identified the anti-asthmatic agent budesonide as an effective inhibitor of P4H activity and subsequent downregulation of CPH, collagen deposition as well as global DNA/histone methylation through enhanced activity of TET/JMJ demethylases, which altogether reduced EMT and metastasis in breast cancer cells [105] (Table 1). This evidence concerns the gene CPE and breast carcinoma.