TGFB1 and neoplasm: On the other hand, TGF-β1 can upregulate NNMT [69], and a recent proteomic study in ovarian TAFs reported that NNMT was upregulated and its expression was necessary and sufficient to elicit hallmarks of activated TAFs, including expression of α-SMA and pro-fibrotic ECM components as well as enhanced contractility, concomitantly with the acquisition of a tumor-promoting phenotype.