On the other hand, following the recent discovery that TGF-β1/Snail1 elicits histone modifications in fibroblast by cooperating with two protein methyltransferases, inhibitors of methyltransferases were tested, including sinefungin and arginine methyltransferase inhibitor 1 (AMI-1) (Table 1), and were found to prevent myofibroblast activity in culture and in vivo, as well as to reduce metastasis in a mouse breast cancer model [65]. The gene discussed is SNAI1; the disease is breast carcinoma.