Similarly, a selective inhibitor of HDACs 1, 3 and 8 impaired the basal and TGF-β-induced activation of murine TAFs and breast cancer TAFs [10], supporting that altered histones may be a key process underlying the aberrant chronification of activated fibroblasts as observed in the desmoplastic tumor stroma. This evidence concerns the gene TGFB1 and breast carcinoma.