Of note, a recent microarray study comparing the exosomal content of high- and low-metastatic cancer cells reported that high-metastatic hepatocellular carcinoma (HCC) cells have a greater capacity to convert normal fibroblasts into TAFs through the secretion of exosomal miR-1247-3p, which directly targets B4GALT3, leading to the activation of β1-integrin/NF-κB signaling in fibroblasts. Here, NFKB1 is linked to hepatocellular carcinoma.