Moreover, it was reported that NNMT expression was necessary and sufficient to elicit a tumor-promoting phenotype in TAFs in vitro and in vivo, revealing that histone methylation has a major role in shaping such a pro-malignant phenotype, and supporting that NNMT or other aberrant methyltransferase activities in TAFs could be a therapeutically interesting target to normalize the tumor stroma [37]. Here, NNMT is linked to neoplasm.