Remarkably, the activation and tumor-promoting traits of TAFs were rescued by inhibition of H3K27 trimethylation with the EZH2 histone methyltransferase inhibitor DZNep as well as the general methyltransferase inhibitor 3-DZA [37], further underscoring the role of altered histones in TAF activation. This evidence concerns the gene EZH2 and neoplasm.