CPE and breast carcinoma: Intriguingly, a recent study reported that an increase in CPH in pluripotent stem cells and breast cancer cells elicited an increase in collagen synthesis concomitantly with a reduced activity of the demethylases TET and JMJ, which require also vitamin C as a cofactor, which in turn yielded an increase in global DNA/histone hydroxylation and H3K9 methylation [105].