Apoptotic inhibitor genes, such as survivin, BIRC5 [35], and API5 [36], were downregulated in both GBM cell lines, with the upregulation of the pro-apoptotic gene, BBC3, in SNB19 cells, whose expression increases in response to diverse apoptotic stimuli [37] (Figure 3I). This evidence concerns the gene BIRC5 and glioblastoma.