In the multivariate analysis, including tumor location, number of metastasis before ICI, ECOG PS, and albumin levels, LIPI was an independent factor for OS (HR for intermediate, 1.43 [95%CI 0.75 to 2.74]; HR for poor, 3.50 [95%CI 1.46 to 8.40], p = 0.03). The gene discussed is ALB; the disease is neoplasm.