Following stimulation with tumor cells, human CD14+CD16+ monocytes increase the production of pro-inflammatory cytokines tumor necrosis factor alpha (TNF-α) and interleukin 12 (IL-12) but reduce the production of anti-inflammatory cytokine interleukin 10 (IL-10), and exert direct cytotoxicity of tumor cells [27]. Here, TNF is linked to neoplasm.