In RCC-bearing mice, IL-1β secreted in TME reprograms TAMs towards an M2-like phenotype by downregulating the expression of interleukin 12B (IL-12B) and nitric oxide synthase 2 (NOS2) and upregulating the expression of IL-10 and arginase-1 [31]. The gene discussed is NOS2; the disease is renal cell carcinoma.