In a KrasLAI-driven lung adenocarcinoma mouse model, CXCR2 ligand, C-X-C motif chemokine ligand 8 (CXCL8), is a transcriptional target of Ras and induces progression of premalignant lesion that is associated with infiltration of neutrophils [110]. Here, CXCL8 is linked to lung adenocarcinoma.