SDHB and hepatocellular carcinoma: Furthermore, Guzy et al. found that SDHB inhibition (Hep3B human hepatoma cells, A549 human alveolar epithelium-derived tumor cells, and 143B human osteosarcoma cells) led to the accumulation of ROS [32], which was later confirmed by SDHB silencing in rat PHEO cells (PC12 cells) [33], mouse PHEO cells (MPC cells) [34,35], immortalized mouse chromaffin cells [36], and human hPheo1 cells [34,35].