In addition to the (epithelial-)mesenchymal transition signaling pathway, several other gene sets linked to aggressive growth of glioblastoma were relatively upregulated in the withinSVZ-samples group, including TNF-α-mediated NF-κB activation, IL-6 induced STAT3 activation, TGF-β signaling, p53 signaling, KRas signaling, genes upregulated by reactive oxygen species, angiogenesis, hypoxia, coagulation, complement activation and inflammatory response. The gene discussed is TNF; the disease is glioblastoma.