Similar to the results obtained with LDH inhibitors, a LDHA/B double knockout reduced the cytosolic Hsp90, Hsp70 and Hsp27 levels in B16F10 and LS174T cells, although the Hsp27 levels could not be detected in B16F10 cells due to a very low Hsp27 expression in murine tumor cells (Figure 3a,b). The gene discussed is LDHA; the disease is neoplasm.