Breast cancer cases were furthermore classified into four combinatorial phenotypic groups as follows: (1) cytoplasmic and nuclear RXRα expression negative (n = 47); (2) cytoplasmic RXRα expression positive only (n = 83); (3) nuclear RXRα expression positive only (n = 75); (4) cytoplasmic and nuclear RXRα expression positive (n = 98). The gene discussed is RXRA; the disease is breast cancer.