Figure 2 shows immunohistochemically stained RXRα images. Positive stained tissue appeared in a brownish color (Figure 2a–c) and negative or unstained cells appeared blue (Figure 2d). Human placenta tissue was used for RXRα negative controls (Figure 1a) and positive controls (Figure 1b). Tumor staining either appeared negative or positive for both nuclear and cytoplasmic RXRα localizations (Table 1). In cases of RXRα expression in both localizations, a nucleo-cytoplasmic IRS ratio was given (Figure 1b). The gene discussed is IARS1; the disease is neoplasm.