Morita and colleagues moved on this direction and recently developed alkylating agent-conjugated pyrrole-imidazole (PI) polyamides that bind to the RUNX DNA consensus in order to prevent the binding of the RUNXs proteins (RUNX1, RUNX2, and RUNX3) to their targets in AML cells with intact p53. The gene discussed is RUNX1; the disease is acute myeloid leukemia.