SLU7 and acute myeloid leukemia: In parallel with the expansion of sequencing technologies, the better understanding of the molecular mechanisms governing HSPCs biology and the lineage choice leading to the balanced production of mature cells has provided the rationale for the identification of novel potential targets/drugs for therapeutic interventions, as in the case of transcription factors, splicing factors, and deubiquitinating enzymes, the new key players in MDS and AML discussed in this review.