By changing the position of the GATA2 myeloid distal enhancer, this rearrangement simultaneously causes a functional downregulation of GATA2 in myeloid precursors and the overexpression of the proto-oncogene EVI1, whose overexpression in HSCs is associated to MDS and AML [110,111,112]. Here, RUNX1 is linked to acute myeloid leukemia.