Interestingly, some genes recurrently mutated in MDS were aberrantly spliced in patients with SF3B1 and SRSF2 mutations (i.e., STAG2); others in patients carrying SRSF2 or U2AF1 mutations (i.e., EZH2 [186] and BCOR). The gene discussed is STAG2; the disease is myelodysplastic syndrome.