Mutations in transcription factors (runt-related transcription factor 1 (RUNX1), GATA-binding protein 2 (GATA2), cut-like homeobox 1 (CUX1), and CCAAT enhancer-binding protein alpha (CEBPa) are also typical in MDS; however, they can occur either early or later in the progression of the disease [13]. The gene discussed is GATA2; the disease is myelodysplastic syndrome.