CD274 and neoplasm: From Figure 5C, we can see that various mechanisms are correlated with larger tumor diameter reduction after treatment, including high mutational burden, higher PD-L1/PD-1 bond threshold for T cell exhaustion, lower PD-L1/PD-1 affinity, lower maximum PD-L1 expression level on cancer cells, higher affinity of the antibody, lower maximum PD-1 expression on T cells, lower antibody clearance rate, lower tumor growth rate, and higher T cell lifespan.