More recently, regorafenib, an oral multi-kinase inhibitor targeting VEGFR-1, -2, -3, TIE 2, PDGFR, FGFR, KIT, RAF-1, RET, and BRAF has been investigated in the randomized phase II trial REGOMA, which has been approved for the management of recurrent glioblastoma by the EMA (European Medicines Agency) [17]; this trial showed a median OS of 7.4 months in the regorafenib arm vs. 5.6 in the lomustine arm. The gene discussed is BRAF; the disease is glioblastoma.