EGFR and glioblastoma: Nowadays, GBM can be diagnosed as a diffuse astrocytic glioma without IDH and H3R gene mutations, with microvascular proliferation, necrosis, and/or peculiar molecular features such as TERT mutation, EGFR amplification, and/or gain of chromosome 7 combined with the loss of chromosome 10 [3,4,5,6].