MKI67 and neoplasm: αSMA+ CAFs had the highest median cell density and H-score (density, 1904 cells/mm2 (IQR 1266–3382); H-score 35.5 (IQR 24.0–51.2)), as compared with respective values for Ki-67+ and caspase-3+ tumor cells (Ki-67+ density, 1087 cells/mm2 (IQR, 433–1909); Ki-67 H-score 7.0 (IQR 3.1–15.5); caspase-3+ density, 203 cells/mm2 (IQR 64–547); caspase-3+ H-score, 0.8 (IQR, 0.3–2.2)) (Wilcoxon p  <  0.001 for all comparisons within density and H-score groups) (Figure 2A).