Overall, the density and spatial analyses suggest a tumor architecture in which αSMA+ CAFs and Ki-67+ tumor cells demonstrate the highest clustering and shortest NN distance, αSMA+ CAFs and caspase-3+ tumor cells have the least amount of clustering and longest NN distance, and cell densities are the highest for αSMA+ CAFs and lowest for caspase-3+ tumor cells. This evidence concerns the gene ACTA1 and neoplasm.