For example, microRNA-21 (miR-21) has been shown to impair lipid metabolism in mice with NAFLD and human liver cancer cell line HepG2 cells, and to inhibit the progression of xenograft tumors induced by HepG2 cells, as miR-21 knockdown can impair lipid accumulation and tumor growth by targeting HMG-Box transcription factor 1 (HBP1)-p53, part of the sterol regulatory element-binding protein 1c (SREBP1c) signaling pathway [42]. This evidence concerns the gene HBP1 and metabolic dysfunction-associated steatotic liver disease.