About 40% of sporadic meningiomas are driven by non-NF2 genetic mutations: these mutations essentially concern grade I meningiomas, where recent large-cohort sequencing studies have identified somatic coding alterations in TRAF7, KLF4, POLR2A, and members of the PI3K and Hedgehog signalling pathways [5]. Here, POLR2A is linked to meningioma.