Other chemokines upregulated in either the tumour or infiltrating immune cells by CHK1i+LDHU, including CCL5 that directly recruits Tregs [51] or CXCL9, CXCL10, CXCL11 that recruit activated effector, T, NK and NKT cells, as well as Tregs [52,53], may also be responsible for the accumulation of Tregs. Here, CCL5 is linked to neoplasm.