Differently, IL-4 inhibition did not affect MOLT-4 resistance to dexamethasone, while IL-13 blockade sensitizes MOLT-4, but not ALL-SIL and RPMI-8402 cell lines, to the action of dexamethasone, thus suggesting that the activation of the pathway is complementary mediated by both cytokines. This evidence concerns the gene IL4 and acute lymphoblastic leukemia.