PCSK9 and cancer: As shown in Figure 2D, PCSK9 inhibitor PF-06446846 had a clear effect on cell proliferation at 100μM concentration in HeLa, OVCAR3 and OVCAR3cis cells, whereas JHSO2 cells that do not express PCSK9 showed minimal sensitivity (85% cell survival), indicating that PCSK9 plays a survival role in these cancer cells.