TNF and neoplasm: In the mouse RAW264.7 macrophage cell line, 17β-estradiol increased transcripts for many chemokines/cytokines, including CCL4, CCL5, CCL12, CCL25, CX3CL1, CXCL2, CXCL10, and CXCL16, IL-1β, TNFα, and CSF-1, as well as those for CCR2, which would augment its response to estrogen-stimulated CCL2 from tumor cells [226] (Supplementary Table S1).