ST6GALNAC1 and Familial prostate cancer: Munkley et al. found that expression of the sialyltransferase ST6GalNAc-I and the cancer-associated sialyl-Tn antigen is regulated by androgens in prostate cancer cells, and is involved in reducing cell adhesion, leading to transformation towards a more mesenchymal-like cell phenotype in a mouse model of prostate cancer, during a process termed epithelial-mesenchymal transition (EMT) [118,119].