More complex is the IHC of p53 for GAC, which has been used as surrogate marker for the CIN subtype in the TCGA, which showed a genetic aberration of TP53 in 71%, and for the MSS/p53− subtype in the ACRG classification [17,18,19,20,21]. The gene discussed is TP53; the disease is cervical squamous intraepithelial neoplasia.