Anti-PD-1 CPIs in relapsed GBM has been the subject of many phase I clinical trials (NCT02017717, NCT02336165, NCT02337491, NCT02054806) (Table 1) shows response rates ranging from 2.5 to 13.3% with anti-PD-1 or anti-PD-L1 monotherapy. This evidence concerns the gene CD274 and glioblastoma.