BRCA2 and colorectal cancer: The authors showed that human DLD1 (colorectal cancer) BRCA2-deficient cells stably transfected with the cDNA of the BRCA2 breast cancer variants S206C or T207A (Table 2), which abolish PLK1 phosphorylation at the latter residue, share similar mitotic phenotypes such as unstable microtubule–kinetochore attachments that result in elevated levels of misaligned chromosomes.