Tenascin-C has been implicated in many cancer types: esophageal, breast, colorectal, bladder, Merkel cell carcinomas, glioma, malignant pleural mesothelioma, glioblastoma multiforme, malignant melanoma, and astrocytoma, and has been implicated in a variety of roles: tumorigenesis, angiogenesis, migration, proliferation, maintaining the stemness of cancer stem cells, and metastasis [31,32,36,37,38,39,40,41]. The gene discussed is TNC; the disease is melanoma.