Since a major part (approximately 100-fold more than free Hsp70) of extracellular Hsp70 originates from small extracellular vesicles and since the compHsp70 ELISA was shown to reliably detect spiked liposomal Hsp70 with a high sensitivity in the blood, it is very likely that elevated Hsp70 levels in the circulation of patients reflect the viable tumor mass. Here, HSPA1A is linked to neoplasm.