EML4-ALK activates the phosphatidylinositol 3-kinase-AKT (PI3K-AKT), reticular activating system (RAS), and Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling cascades, which affect tumor progression, survival, and growth, and by extension other organ metastases, such as the central nervous system (CNS) metastases [10,11]. The gene discussed is AKT1; the disease is neoplasm.