Malignant cells are also able to induce the adjacent stromal cells to acquire a tumor-supporting behavior by secreting soluble factors such as epidermal (EGF), platelet-derived (PDGF), vascular endothelial (VEGF) and fibroblast (FGFs) growth factors and TGF-β or by releasing microvesicles, such as exosomes, to vehicle RNA molecules or proteins. This evidence concerns the gene VEGFA and neoplasm.