TAMs usually have an M2 phenotype, are responsive to anti-inflammatory factors such as IL-4, IL-13 and IL-10 and secrete C-C motif chemokine ligands 2, 17 and 22 (CCL2, CCL17 and CCL22) and transforming-factor β (TGF-β), thus inducing tumor growth and dissemination. Here, CCL2 is linked to neoplasm.