VEGFA and neoplasm: The differential localization of these two populations of TAMs coincides with the expression of anti-inflammatory and proangiogenic factors such as IL-1 receptor antagonist (IL1-RN) [76] and VEGF at the tumor core, suggesting that these cells crosstalk with ECs and GSCs within the PVN to further support and amplify the expansion of tumor vasculature with irregular morphology and ECM remodeling [75].