A genetic mouse study of pancreatic cancer using haplodeficient oxygen sensor prolyl hydroxylase domain proteins (Phd)2 (Phd2+/−) model and Phd2Cre/+ mice model harboring conditional Phd2 haplodeficiency in ECs reported normalization of endothelial lining and vascular maturation in vivo [179]. Here, EGLN1 is linked to familial pancreatic carcinoma.