IL6 and neoplasm: Vasculogenic mimicry is often observed in the hypoxic tumor microenvironment and is characterized by an increase in HIF-1α/MMP-9/VEGF signaling [39], the activation of epithelial-mesenchymal transition (EMT)-related proteins such as Twist1 [40,41,42], and an upregulation of proinflammatory molecules such as IL-6 [43].