CD4 and neoplasm: For immunohistochemistry, human tumor sections were incubated with anti-CD4 (1:200, ab133616, Abcam), anti-CXCL13 (1:200, AF801, R&D), anti-IL-21(1:200, ab5978, Abcam), anti-CD8 (1:300, ab237709, Abcam), and anti-CD20 (1:300, ab78237, Abcam) antibodies; mouse tumor sections were incubated with anti-CD8 (1:500, ab209775, Abcam), anti-CD20 (1:500, ab122788, Abcam), and anti-CD138 (1:200, ab181789, Abcam) antibodies.