Here, I provide a proof of principle of this autologous cell defection approach in four cell lines in which a growth factor was knocked out: IGF2 (insulin-like growth factor 2) in βTC neuroendocrine pancreatic cancer cells (βTC-ΔIGF2 clone); IL6 (interleukin 6) in U266B1 multiple myeloma cells (U266B1-ΔIL6 clone) and in A549 lung cancer cells (A549-ΔIL6 clone); and PDGFD (platelet-derived growth factor D) in NCIH28 mesothelioma cells (NCIH28-ΔPDGFD clone). This evidence concerns the gene PDGFD and plasma cell myeloma.