For example, DCexos from DCs treated with poly(I:C) have been shown to be the most efficient in a model of B16-OVA melanoma in vivo compared to other TLR ligands, inducing robust activation of melanoma-specific CD8 T cells in tumor-draining lymph nodes, spleen, and tumor tissues and recruited NK and NKT cells to the tumor site, resulting in drastic inhibition of tumor growth and an increase in survival in tumor-bearing animals [100]. The gene discussed is CD8A; the disease is melanoma.