CD8A and neoplasm: On the other hand, a previous study found that mutations in genes involved in chromatin remodeling, such as AT-Rich Interaction Domain 2 (ARID2), were also associated with an immunosuppressive tumor microenvironment through the expression of genes involved in the induction of M2 macrophages [14], although there were no associations between mutations of the genes involved in chromatin remodeling and the degree of CD8+ TILs as well as PD-L1 expression [33].