In tumor immunity, M1 macrophages produce inflammatory cytokines such as tumor necrosis factor α (TNF-α), IL-6 and IL-12, and exert an anti-tumor effect, whereas M2 macrophages produce immunosuppressive cytokines such as IL-10 and TGF-β, and inhibit anti-tumor immune reactions [20]. This evidence concerns the gene IL6 and neoplasm.