KRAS-mediated repression of interferon regulatory factor 2 (IRF) results in the high expression of the chemokine C-X-C motif ligand 3 (CXCL3), which induces MDSCs that express C-X-C motif chemokine receptor 2 (CXCR2) as the receptor of CXCL3 in tumor tissues [50]. The gene discussed is CXCL3; the disease is neoplasm.