AKT1 and hepatocellular carcinoma: We have previously reported that while activating mutations of the PI3K/AKT signaling pathway are associated with increased expression of PD-L1 in HCC, and the volume of TILs is generally high in PD-L1-positive HCC, TILs are deficient in HCCs with activating mutations of the PI3K/AKT signaling pathway [33].