SIK2 and ovarian cancer: Similarly, inhibition of SIK2 in a second ovarian cancer cell line, A2780, also caused a dose-dependent and significant reduction in the mitotic indices compared to DMSO treated cells (DMSO, 34.2%; 1 μM MRIA9, 25.2%; 5 μM MRIA9, 18.5%) (Figure S2A,B).