We found individual gene differences between subtypes, including more alterations in EGFR, RBM10, and TERT in lepidic (LEP) tumors, compared with acinar (ACI) and papillary (PAP) tumors and MIP and SOL tumors, and more alterations in TP53, SETD2, MGA, and SMARCA4 in MIP and SOL tumors, compared with ACI and PAP tumors and LEP tumors [14]. The gene discussed is RBM10; the disease is pulmonary alveolar proteinosis.