Reportedly, the alteration of biochemical parameters including Hb, M-protein, lactic acid dehydrogenase (LDH), PLT, ALB, β2-MG, and CRP in combination with the deregulated profile of circulating miRNAs expression is estimated to predict MM progression and patient outcome [14,36,48] (Table 2). This evidence concerns the gene CRP and Miyoshi myopathy.