As a member of the family of the nucleotide-binding oligomerization domain-like receptors (NLRs), cytokine NALP3, also known as nod-like receptor protein 3 (NLRP3), is encoded by gene NLRP3, playing an important role in the MSU-mediated gout inflammation and immune regulation [12]. The gene discussed is NLRP3; the disease is gout.