HMOX1 and malignant colon neoplasm: Similarly, it has been observed that the higher activity of the key catalytic enzyme GPx1 promote the progression of distinct types of cancer, including colon cancer, which is in line with the overexpression observed after the highest dose of ENs mixture employed in female rats [41,42] As regard the intestinal inflammation modulator Hmox1, it has been shown to inhibit the activation of apoptotic pathways in different cell lines but in this case, did not show significant changes in its expression [43].