The adverse reactions encountered were abdominal discomfort, leg pain, low back pain, and catching a cold in the AGM group (one participant each) and AST, ALT, and γ-GT elevation; HbA1c and glucose increase; catching a cold or flu; gastroesophageal reflux; and triglyceride elevation in the placebo group (also in one participant each). This evidence concerns the gene GPT and gastroesophageal reflux disease.