The gastric emptying was more delayed in the functional dyspepsia group compared with the pancreatic fibrosis group (38.5% vs. 20%, p-value: 0.04), and chromogranin-A expression in duodenal mucosa was increased in the pancreatic fibrotic group with age-matched comparison (p-value: 0.04) Western blot analysis of the other two proteins, cholecystokinin and glucagon-like peptide 1, showed no significant difference between the pancreatic fibrotic and functional dyspepsia groups. Here, CHGA is linked to dyspepsia.