Through the secretion of IL-10, these B cells can attenuate TH1, TH2 or TH17 cell-mediated immune responses in murine models of autoimmune, inflammatory and infectious diseases (reviewed in [36]) and inhibit anti-tumor cytotoxic T cell responses in mouse models of colorectal cancer and melanoma (reviewed in [39,40]). This evidence concerns the gene IL10 and melanoma.