Next, GeneGo Metacore annotations of enriched biological processes revealed that genes coexpressed with DPP3 were involved in cell-cycle-related pathways and networks, such as “Cell cycle_Role of APC in cell cycle regulation”, “Cell cycle_Spindle assembly and chromosome separation” and “DNA dam-age_ATM/ATR regulation of G2/M checkpoint: cytoplasmic signaling” playing essential roles in breast cancer patients (Supplementary Figure S3, Table S1). This evidence concerns the gene APC and breast cancer.